The first analyses of TIGER focused on a set of key co-morbidities frequently reported by tinnitus patients: temporo-mandibular joint (TMJ) disorders, headaches and hyperacusis. In 3 sequential studies, TIGER shows the lack of sex-influences in their association with tinnitus. Thanks to a deep phenotyping strategy, TIGER proposes that the mechanisms underlying tinnitus with hyperacusis are distinct from those associating tinnitus with TMJ or headache.
"Impact of Temporomandibular Joint Complaints on Tinnitus-Related Distress"
Edvall NK, Gunan E, Genitsaridi E, Lazar A, Mehraei G, Billing M, Tullberg M, Bulla J, Whitton J, Canlon B, Hall DA, Cederroth CR.
Frontiers in Neuroscience 2019 Aug 22;13:879. doi: 10.3389/fnins.2019.00879
"Relationship between headaches and tinnitus in a Swedish study"
Lugo A, Edvall NK, Lazar A, Mehraei G, Lopez-Escamez JA, Bulla J, Uhlen I, Canlon B, Gallus S, Cederroth CR.
Scientific Reports 2020 May 22;10(1):8494. doi: 10.1038/s41598-020-65395-1.
"Association between hyperacusis and tinnitus"
Cederroth CR, Lugo A, Edvall NK, Lazar A, Mehraei G, Lopez-Escamez JA, Bulla J, Uhlen I, Hoare DJ, Baguley DM, Canlon B, Gallus S.
Journal of Clinical Medicine. 9(8), 2412. (2020) doi: 10.3390/jcm9082412