L'acufene: un disturbo dell'orecchio da non sottovalutare


The team in Mario Negri Institute recently describes their important contribution to tinnitus on their website so to inform the Italian population on the activities and scopes of TIGER. For those understanding Italian, please follow the link below!


Severe tinnitus runs in families!

We previously showed that tinnitus can be affected by genetics, but given the heterogeneity of the condition, it was unclear as yet which forms are more influenced than others. We recently published that severe tinnitus is very likely to be transmitted within the family, with risks increasing up to 9 times if a sibling has tinnitus, which is close to what is known for schizophrenia! Furthermore, there is a strong sex-bias, with women being more likely to be genetically impacted than men.
These are very important insights for future genetic studies on tinnitus, which emphasize focusing on severity and stratifications by sex!
We also call for redefining tinnitus, as less severe and more common forms may not be "disease-like". We believe that severe tinnitus is the relevant condition for focusing research on and better screens such as those performed in STOP should help refine this characterization in tinnitus research.
Trpchevska N, Bulla J, Prada Hellberg M, Edvall NK, Lazar A, Mehraei G, Uhlen I, Schlee W, Canlon B, Gallus S, Lopez-Escamez JA, Cederroth CR.
Journal of Clinical Medicine. 9(12), 3812 (2020) doi: 10.3390/jcm9123812

3 publications on key tinnitus co-morbidities published by TIGER


The first analyses of TIGER focused on a set of key co-morbidities frequently reported by tinnitus patients: temporo-mandibular joint (TMJ) disorders, headaches and hyperacusis. In 3 sequential studies, TIGER shows the lack of sex-influences in their association with tinnitus. Thanks to a deep phenotyping strategy, TIGER proposes that the mechanisms underlying tinnitus with hyperacusis are distinct from those associating tinnitus with TMJ or headache. 



"Impact of Temporomandibular Joint Complaints on Tinnitus-Related Distress"
Edvall NK, Gunan E, Genitsaridi E, Lazar A, Mehraei G, Billing M, Tullberg M, Bulla J, Whitton J, Canlon B, Hall DA, Cederroth CR.
Frontiers in Neuroscience 2019 Aug 22;13:879. doi: 10.3389/fnins.2019.00879 

"Relationship between headaches and tinnitus in a Swedish study"
Lugo A, Edvall NK, Lazar A, Mehraei G, Lopez-Escamez JA, Bulla J, Uhlen I, Canlon B, Gallus S, Cederroth CR.
Scientific Reports 2020 May 22;10(1):8494. doi: 10.1038/s41598-020-65395-1.

"Association between hyperacusis and tinnitus"
Cederroth CR, Lugo A, Edvall NK, Lazar A, Mehraei G, Lopez-Escamez JA, Bulla J, Uhlen I, Hoare DJ, Baguley DM, Canlon B, Gallus S. 
Journal of Clinical Medicine. 9(8), 2412. (2020) doi: 10.3390/jcm9082412



TIGER coordinator receives 2 research prizes!

Dr. Cederroth, coordinator of TIGER, has been awarded the 2020 Tinnitus and Hearing Research Prize from the "Deutsche Stiftung Tinnitus & Hören Charité" and the Geraldine Dietz Fox Young Investigator Award from the "Association for Research in Otolaryngology" for his hearing and tinnitus research. He was selected as the recipient of the award "for the importance of his research goals in the field; genetic influences on tinnitus, the extent and progress of his research program and the potential for effective progress ”.


 KI news:

Christopher Cederroth recipient of prestigious award in hearing and tinnitus research

Christopher Cederroth receives the Geraldine Dietz Fox Young Investigator Award


Additional references

ARO Young investigator award

Research Prize Tinnitus and Hearing

A link between tinnitus and suicide attempts identified

The impact of tinnitus on quality of life is poorly understood. There are individual reports of suicide cases, but large studies are lacking. We now published a short report which shows that an increased risk of suicide attempts in a representative population from the Stockholm area is associated with tinnitus and that this risk exists in women but not in men. Of note, we show that for those who have received special care, this risk is gone. Our study highlights the benefits of special care to reduce the risk of suicide attempts and emphasizes the need of greater resources for tinnitus rehabilitation, especially in Sweden.

However, we would like to inform you that suicide attempts do not mean completed suicides. Although suicidal ideation is common, suicide attempts are less frequent, even less so for suicide. Studies of completed suicides would require large national studies to achieve sufficient effect and determine the effect of tinnitus on this.

We would like to thank donations that have helped make this article open-access and accessible to the whole community.



"Sex-Specific Association of Tinnitus With Suicide Attempts"

Lugo A, Trpchevska N, Liu X, Biswas R, Magnusson C, Gallus S, Cederroth CR
JAMA Otol  2019 May 02. doi:10.1001/jamaoto.2019.0566

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Key Facts

  • Coordinator:Christopher R. Cederroth, Karolinska Institutet
  • 1 million € funding
  • 4 coordinating centers
  • 3 associated partners
  • Goal:Development of risk predictors
  • EU Project Overview: http://gender-net-plus.eu/